Washington University in St. Louis

The Patti Lab
Metabolomics to elucidate novel biochemical mechanisms of disease
Job Opportunities
Job opportunities are available.

Selected Publications

Goldner NK, Bulow C, Cho K, Wallace M, Hsu F-F, Patti GJ, Burnham C-A, Schlesinger P, and Dantas G
Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum
mSphere, in press, 2018
doi:10.1128/mSphereDirect.00371-18

d'Avignon A, Puchalska P, Ercal B, Jang YJ, Martin SE, Graham MJ, Patti GJ, Han X, and Crawford PA
Hepatic Ketogenic Insufficiency Reprograms Hepatic Glycogen Metabolism and the Lipidome
Journal of Clinical Investigation Insight, 3(12):e99762, 2018
doi:10.1172/jci.insight.99762

Llufrio EM, Wang L, Naser FJ, and Patti GJ
Sorting Cells Alters Their Redox State and Cellular Metabolome
Redox Biology, 16,381-387, 2018
doi:10.1016/j.redox.2018.03.004

Yao C-H, Liu G-Y, Wang R, Moon SH, Gross RW, and Patti GJ
Identifying Off-Target Effects of Etomoxir Reveals that Carnitine Palmitoyltransferase 1 is Essential for Cancer Cell Proliferation Independent of B-Oxidation
PLOS Biology, 16(3):e2003782, 2018
doi:10.1371/journal.pbio.2003782/a>

Wang L, Naser FJ, Spalding JL, and Patti GJ
A Protocol to Compare Methods for Untargeted Metabolomics
Methods in Molecular Biology, in press, 2018
doi:xxxxx/a>

Ramachandran R, Huang X, Floberg J, Elhamalli AE, McCormick ML, Patti GJ, Spitz DR, and Schwarz JK
Radioresistant Cervical Cancers are Sensitive to Inhibition of Glycolysis and Redox Metabolism
Cancer Research, 78(6), 1392-1403, 2018
doi:10.1158/0008-5472.CAN-17-2367

Gelman SJ, Naser FJ, Mahieu NG, McKenzie LD, Dunn GP, Cheeda MG, and Patti GJ
Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress
Cell Reports, 22, 512-522, 2018
doi:10.1016/j.celrep.2017.12.050

Naser FJ, Mahieu NG, Wang L, Spalding JL, Johnson SL, and Patti GJ
Two Complementary Reversed-Phase Separations for comprehensive Coverage of the Semipolar and Nonpolar Metabolome
Anal. Bioanal. Chem., 410(4), 1287-1297, 2017
doi:10.1007/S00216-017-0768-x

Mahieu NG and Patti GJ
Systems-Level Annotation of a Metabolomics Data Set Reduces 25,000 Features to Fewer than 1,000 Unique Metabolites
Anal. Chem., 89(19), 10397-10406, 2017
doi:10.1021/acs.analchem.7b02380

Dennis KK, Marder E, Balshaw DM, Cui Y, Lynes MA, Patti GJ, Rappaport SM, Shaughnessy DT, Vrijheid M, Barr DB
Biomonitoring in the Era of the Exposome
Environ Health Perspect, 125:502-510, 2017
doi:10.1289/EHP474

Chen Y-J, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, and Patti GJ
Lactate Metabolism is Associated with Mammalian Mitochondria
Nature Chemical Biology, 12, 937-943, 2016
doi:10.1038/nchembio.2172

Mahieu NG, Spalding J, Gelman S, Patti GJ
Defining and Detecting Complex Peak Relationships in Mass Spectral Data: The mz.unity Algorithm
Anal. Chem., 88(18), 9037-9046, 2016
doi:10.1021/acs.analchem.6b01702

Yao C-H, Liu G-Y, Yang K, Gross RW, Patti GJ
Inaccurate Quantitation of Palmitate in Metabolomics and Isotope Tracer Studies Due to Plastics
Metabolomics, 12(143), 2016
doi:10.1007/s11306-016-1081-y

Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells
Immunity, 45(1), 60-73, 2016
doi:10.1016/j.immuni.2016.06.011

Yao C-H, Grider RF, Mahieu NG, Liu G-Y, Chen Y-J, Wang R, Singh M, Potter GS, Gross RW, Schaefer J, Johnson SL, Patti GJ
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts
Cell Chemical Biology, 23, 1-11, 2016
doi:10.1016/j.chembiol.2016.03.007
     Highlighted in Cell Chemical Biology 23, 431-432, 2016
     Liposuction: Extracellular Fat Removal Promotes Proliferation
     doi:10.1016/j.chembiol.2016.04.003

Gelman S, Patti GJ
Profiling Cancer Metabolism at the 'Omic Level: A Last Resort or the Next Frontier?
Cancer & Metabolism, (2016) 4:2, 2016
doi:10.1186/s40170-016-0144-x

Spalding J, Cho K, Mahieu NG, Nikolskiy I, Llufrio EM, Johnson SL, Patti GJ
Bar Coding MS2 Spectra for Metabolite Identification
Anal. Chem., 88(5), 2538-2542, 2016
doi:10.1021/acs.analchem.5b04925

Mahieu NG, Genenbacher JL, Patti GJ
A Roadmap for the XCMS Family of Software Solutions in Metabolomics
Current Opinion in Chemical Biology, 30, 87-93, 2016
doi:10.1016/j.cbpa.2015.11.009

Mahieu NG, Spalding S, Patti GJ
Warpgroup: Increased Precision of Metabolomic Data Processing by Consensus Integration Bound Analysis
Bioinformatics, 32(2), 268-275, 2016
doi:10.1093/bioinformatics/btv564

Gelman S, Mahieu NG, Cho K, Llufrio EM, Wencewicz TA, Patti GJ
Evidence that 2-Hydroxyglutarate is Not Readily Metabolized in Colorectal Carcinoma Cells
Cancer & Metabolism, (2015) 3:13, 2015
doi:10.1186/s40170-015-0139-z

Zamboni N, Saghatelian A, Patti GJ
Defining the Metabolome: Size, Flux, and Regulation
Molecular Cell, 58(4), 699-706, 2015
doi:10.1016/j.molcel.2015.04.021

Nikolskiy I, Siuzdak G, Patti GJ
Discriminating Precursors of Common Fragments for Large-Scale Metabolite Profiling by Triple Quadrupole Mass Spectrometry
Bioinformatics, 31(12), 2017-2023, 2015
doi:10.1093/bioinformatics/btv085

Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA
Ketogenesis Prevents Diet-Induced Fatty Liver Injury and Hyperglycemia
J Clin Invest., 124(12), 5175-5190, 2014
doi:10.1172/JCI76388

Beirowski B, Babetto E, Golden JP, Chen Y-J, Yang K, Gross RW, Patti GJ, Milbrandt J
Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance
Nature Neuroscience, 17, 1351-1361, 2014
doi:10.1038/nn.3809

Cho K, Mahieu NG, Ivanisevic J, Uritboonthai W, Chen Y-J, Siuzdak G, Patti GJ
isoMETLIN: A Database for Isotope-Based Metabolomics
Anal. Chem., 86(19), 9358-9361, 2014
doi:10.1021/ac5029177

Mahieu NG, Huang X, Chen Y-J, Patti GJ
Credentialed Features: A Platform to Benchmark and Optimize Untargeted Metabolomic Methods
Anal. Chem., 86(19), 9583-9589, 2014
doi:10.1021/ac503092d

Chen Y-J, Hill S, Huang H, Taraboletti A, Cho K, Gallo R, Manchester M, Shriver LP, Patti GJ
Inflammation Triggers Production of Dimethylsphingosine from Oligodendrocytes
Neuroscience, 279(2014), 113-121, 2014
doi:10.1016/j.neuroscience.2014.08.011

Chen Y-J, Huang X, Mahieu NG, Cho K, Schaefer J, Patti GJ
Differential Incorporation of Glucose into Biomass during Warburg Metabolism
Biochemistry, 53(29), 4755-4757, 2014
doi:10.1021/bi500763u

Cho K, Mahieu NG, Johnson SL, Patti GJ
After the feature presentation: technologies bridging untargeted metabolomics and biology
Current Opinion in Biotechnology, 28, 143-148, 2014
doi:10.1016/j.copbio.2014.04.006

Huang X, Chen Y-J, Cho K, Nikolskiy I, Crawford PA, Patti GJ
X13CMS: Global Tracking of Isotopic Labels in Untargeted Metabolomics
Anal. Chem., 86(3), 1632-1639, 2014
doi:10.1021/ac403384n

Nikolskiy I, Mahieu NG, Chen Y-J, Tautenhahn R, Patti GJ
An Untargeted Metabolomic Workflow to Improve Structural Characterization of Metabolites
Anal. Chem., 85(16), 7713-7719, 2013
doi:10.1021/ac400751j

Goeddel L, Patti GJ
Maximizing the Value of Metabolomic Data
Bioanalysis, 18, 2199-2201, 2012
doi:10.4155/BIO.12.210

Patti GJ, Yanes O, Siuzdak G
Metabolomics: The Apogee of the Omic Triology
Nature Reviews, 13(4), 263-269, 2012
doi:10.1038/nrm3314

Patti GJ, Yanes O, Shriver L, Courade JP, Tautenhahn R, Manchester M, Siuzdak G
Metabolomics Implicates Altered Sphingolipids in Chronic Pain of Neuropathic Origin
Nature Chemical Biology, 8, 232-234, 2012
doi:10.1038/nchembio.767

Patti GJ
Separation Strategies for Untargeted Metabolomics
Journal of Separation Science, 34(24): pages 3460-3469, 2011
doi:10.1002/jssc.201100532

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Washington University, Departments of Chemistry, Genetics, and Medicine. Saint Louis, Missouri 63110 USA