Gelman S, Patti GJ
Profiling Cancer Metabolism at the 'Omic Level: A Last Resort or the Next Frontier?
Cancer & Metabolism, (2016) 4:2, 2016
When profiling metabolites, there are two general experimental paradigms: untargeted studies at the omic scale and targeted studies which usually focus on a much smaller subset of compounds. Although untargeted studies have become increasingly fashionable and are often perceived to be the cutting edge, it is important to recognize that they have limitations and are not always the better experiment. In theory, an untargeted analysis profiles all of the same metabolites as a targeted analysis, plus more. So why is more not always better?